A cura di: Dott. Giovanna Gentile

UOD Diagnostica Molecolare Avanzata Tel. 0633775457 - dima@ospedalesantandrea.it

 

 

Polimorfismi del DNA correlabili al metabolismo degli inibitori di

HMG-CoA reduttasi  (STATINE)

 

 

 

 

Codici prescrizione: 2 ricette

 

1) DA160 - DA161-  LA646 X 6 (nota: STAT1)

2) LA646 X 8 (nota: STAT2)

 

Polimorfismi analizzati:

 

 

 

HMGCR -911C>A                                 rs3761740                                                       

HMGCR Ile585Val (A>G)                       rs5908                                    

SLCO1B1                                            rs4363657        

SLCO1B1 T521C                                  rs4149056        

CYP3A4*22                                          rs35599367      

CYP2C8 *7/*8                                      rs72558195      

APOA1 -75G>A                                    rs1799837        

APOB R3500Q                                      rs5742904      

CETP                                                    rs1532624                   

 

 

PON A575G (Gln192Arg)                       rs662   

PON1 C-108T                                       rs705379                                 

CYP2C9*2  (C>T)                                 rs1799853                               

CYP2C9*3 (A>C)                                  rs1057910                                           

CYP3A4*1B                                         rs2740574                                                       

CYP3A5*3                                           rs776746                                                        

ABCB1 C3435T                                    rs1045642                                                       

MRP2 (ABCC2) Val1188Glu (T>A)         rs17222723                  

MRP2 (ABCC2) Cys1515Tyr (G>A)        rs8187710                   

ABCC2 C-24T                                       rs717620